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The group of drugs called tricycle antidepressants include Sinequan (Doxepin hydrochloride). Sinequan is an antidepressant with anxiolytic properties used to treat depression and anxiety. This drug is known under different brand names such as Aponal, Adapine, Sinquan and lastly Sinequan.

Sinequan Information

Sinequan affects unbalanced chemicals in the brain with a dual action and inhibits the reuptake of noradrenalin and serotonin from the synaptic cleft. Doxepin has a strong local-anesthetic action and like all other antidepressants it has a sodium channel blocking activity.

The medicine is effective for those whose depression or anxiety is psychological, associated with alcoholism, or associated with severe mental illness. Sinequan helps relieve tension, increase energy, improve sleep, and ease the feelings of guilt, worry and fear.

Drug abuse, dependence and suicidal patients

* Sinequan has a low potential for psychological dependence and abuse. There are some symptoms that may appear when the treatment with Doxepin suddenly stops including extreme worry, panic attacks, irritability, frenzied abnormal excitement, rebound depression, etc. This can be avoided if the daily dose is reduced gradually by approximately 25% each week.

* Patients with suicidal thoughts or previous suicidal attempts should be closely monitored if they are under treatment with Sinequan.

* Doxepin may also worsen other psychotic conditions like schizophrenia, and in this case the antipsychotic treatment should not be stopped.

This medication may endanger your reaction times or cause difficulties in thinking so avoid any activities that require you to stay awake and alert. Avoid alcohol as well and additionally grapefruit juice because of potential interactions with the medicine.

An overdose of Sinequan can be fatal. The most common symptoms associated with this medication are blurred vision, vomiting, confusion, muscle stiffness, felling too cold or too hot, convulsions, hallucinations, and even coma.

If you have any of the following conditions you may not be able to use Sinequan or you may need a special adjustment of the medicine:

- a bipolar disorder
- diabetes
- any organic brain disorders
- hypertrophy of the prostate with urine retention
- any intoxications with analgesics, alcohol or sedatives
- preexisting cardiac damage (arrhythmias, insufficiency)

For those who are younger than 24 years old thoughts of suicide may appear so let your doctor know if your symptoms of depression or suicidal thoughts worsen during the treatment.

Sinqeuan may be harmful to an unborn baby or to a nursing one.

Like any other drugs, side effects can occur and may include:

- delirium, rarely induction of hypomania and schizophrenia
- difficulties in urinating, dry mouth, perception of glaucoma
- postural collapse
- massive weight gain, frequently impaired sexual function in men
- photosensitivity, agranulocytosis
- hypotension, hypo-plastic anemia

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