Tegretol - Take Control Of Your Mood With Tegretol
December 2nd, 2008

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Sold under the name of Tenegrol, carbamazepine is an anticonvulsant and mood stabilizing drug. This antimanic medication is used to control certain types of seizures in the treatment of epilepsy, to treat bipolar disorder, and is sometimes used in the treatment of schizophrenia and trigeminal neuralgia.

Tenegrol Information

Walter Schindler discovered carbamazepine in 1953 in Basel, Switzerland and then synthetized the drug in 1960. Tenegrol was approved to be right for the treatment of trigeminal neuralgia in 1962. This drug relieves pain associated with trigeminal neuralgia disease often within 24 to 48 hours.

Tenegrol has been observed in some patients to have a mild psychotropic effect which could help prevent psychomotor or temporal lobe epilepsy. The medicine when given in combination with lithium or another neuroleptic or an immunotherapy has been found useful in the treatment of acute mania and the prophylactic treatment of manic-depressive disorders. Also Tenegrol is used in patients with central partial diabetes insipidus (water diabetes), severe mental illness (psychotic disorders), and alcohol withdrawal.

Being an enzyme inducer of the cytochrome P450 system which metabolizes oral contraceptive, Tegretol renders certain methods of hormonal contraception.

Like any other tricylic compound, Tegretol has a moderate anticholinergic action which may cause certain adverse effects of the drug. Some of these effects may include:

- drowsiness; upset stomach
- blurry or double vision
- temporary or mild loss of blood cells or platelets
- small reductions in white cell count
- syndrome of inappropriate anti-diuretic hormone (SIADH)
- juvenile myoclonic epilepsy

The mechanism of action of Tenegrol is well understood - voltage-gated sodium channels are molecular pores that allow neurons to generate action potentials (the events that allow neurons to communicate over long distances); in order to start the action potential they close the channel and carbamazepine makes the brain cells less excited thereby stabilizing the inactivated state of sodium channels.

Tenegrol should not be advised for patients having:

- acute intermittent porphyries
- serious blood disorder
- hepatic disease
- with or after an MAO (monoamine oxidase) inhibitor

- hypersensitivity to any of the tricyclic compounds
- to patients presenting AV heart block
- pregnancy (it causes neural tube defects for the fetuses)
- behavioral problems
- kidney or liver disease
- diabetes mellitus (sugar diabetes)

The medicine should be taken regularly, at the same time everyday, with or without food. Grapefruit or its juice may affect the amount of the drug in your blood so it is recommended to avoid the fruit while taking Tegretol.

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