Reasons To Avoid Chloromycetin Palmitate
December 2nd, 2008

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Chloromycetin palmitate represents an antibiotic that is seldom used over the territory of the United States because it may determine serious side-effects. Even though at a certain moment in time it was regarded as one of the most efficient agent capable to neutralize both gram-positive and gram-negative bacteria, chlamydiae, rickettsia and spirochetes, doctors prefer nowadays to recommend an alternative medication. This type of antibiotic has been discovered in 1947 and ever since it has been used intensively. First of all, it played an important role in a certain type of meningitis. More specifically, if the health condition was provoked by Haemophilus influenzae, Streptococcus pneumonia, and Neisseria meningitides, it could be treated, or at least kept under control, by using chloromycetin palmitate.

Chloromycetin Palmitate and Meningitis

A test that has been performed at the Department of Pediatrics and Medicine from University of Maryland proved that chloromycetin palmitate may be successfully used for treating meningitis. Twenty-three people that suffered from pyogenic meningitis represented the subject of the test. The treatment consisted only of chloramphenicol, which is the active agent of the chloromycetin palmitate. In 12 of the cases, chloromycetin hydrochloride had been administered intravenously. This represented the treatment in the early stages. The preservation treatment consisted of chloromycetin palmitate. The other 11 cases followed a treatment based only on chloromycetin palmitate, which was administered orally. The blood and the spinal fluid were discovered to contain concentration of antibiotic in amounts that could be quantifiable. Twenty-two of the patients were cured while the last of them died. The child that could not be cured had been in a very severe condition. He received the treatment from the 8th day of disease. From the ones that participated to the test, 12 had meningitis provoked by Haemophilus influenzae, 8 by N. intracellularis and 3 by D. pneumoniae.

Adverse Effects of Chloromycetin Palmitate

Some of the side-effects of chloromycetin palmitate depend on the dosage that is administered to the patient while others are independent of this factor. The first ones include hematologic effects such as bone marrow suppression and hemolytic anemia, cardiac side-effects such as cardiovascular collapse (which is also known as the gray baby syndrome), neurologic, such as optic or peripheral neuritis, encephalopathy, headaches and depression. Many other side-effects, which are less severe, may be observed. Nausea, vomiting, diarrhea, hypersensitivity reactions, pseudomembranous colitis, and ototoxicity may also be dependent of the dose. On the other side, adverse effects such as idiosyncratic aplastic anemia are not influenced by the amount of chloromycetin palmitate that is used.

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