A Brief Review Of Danocrine
December 1st, 2008

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Danocrine is the trade name of the drug, Danazol, a synthetic steroid derived from Ethisterone. It is supplied in 50, 100 and 200 mg capsules for oral use. It is commonly used in treatment for Endometriosis, Fibrocystic breast disease and hereditary Angioedema.

When should Danocrine not be used?

Danocrine should not be used by pregnant or nursing women. Use of Danocrine by pregnant women can result in androgenic effects to the female fetus. It should also be avoided by patients who have undiagnosed abnormal genital bleeding, Porphyria, or significantly impaired renal, cardiac or hepatic function.

What precautions should be used by those taking Danocrine?

Because Danocrine may cause a degree of fluid retention, physical conditions which may be influenced by this factor, such as epilepsy, migraine head aches and cardiac or renal dysfunction, require careful observation and documentation to avoid complications. Danocrine also has a known drug interaction with the drug Warfarin, causing a noteable increase in Carbamzepine levels in patients taking both drugs.
Additionally, since hepatic dysfunction manifested by modest increases in serum transaminases levels has been reported in patients treated with Danocrine, period liver function testing is advisable. Administration of Danocrine has been reported to cause manifestations of acute intermittent porphyria.
What does Danocrine do?
Danocrine works by suppressing the pituitary-ovarian axis. The medication is thought to achieve this effect by a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of danazol with sex hormone receptors.
The drug absorbs into the blood stream at a much faster rate when taken with food and it is interesting to note that the plasma concentrations of the drug do not increase in proportion to the amount of the drug delivered. In studies where volunteers were given dosages of 100mg and 200mg, it was found that when the dosage was doubled, plasma levels of the drug only gained 35 to 40%.
Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic when being used to treat endometriosis. The consequent changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danocrine on the pituitary-ovarian axis. A complete cure of endometrial lesions occurs in the most cases.
When the drug is used to treat fibrocystic breast disease, a complete disappearance of the disease's characteristic nodules is usually noted, as well as the elimination of pain and tenderness in the breast area. The treatment does tend to result in an irregular menstrual pattern but this is usually reversed within sixty to ninety days of the discontinuation of Danocrine therapy.

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