A Little Information About Danocrine
December 1st, 2008

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Danocrine, also known as Cyclomen, is the trade name of the drug, Danazol, a synthetic steroid derived from Ethisterone. Danazol is a white to pale yellow crystalline powder which is insoluble in water and has very low solubility in alcohol. It is supplied in 50, 100 and 200 mg capsules for oral use.

When should Danocrine not be used?

Danocrine should not be used by pregnant or nursing women. Use of Danocrine by pregnant women can result in androgenic effects to the female fetus. It should also be avoided by patients who have undiagnosed abnormal genital bleeding, Porphyria, or significantly impaired renal, cardiac or hepatic function.

What precautions should be used by those taking Danocrine?

Patients with diabetic conditions should be in close contact with their medical professional before beginning a Danocrine treatment. The drug can cause a serious raise in blood sugar levels and must be monitored carefully to avoid this danger. Additionally, those with liver disease or at risk for blood clots should be closely monitored while taking this drug.

Because Danocrine may cause a degree of fluid retention, physical conditions which may be influenced by this factor, such as epilepsy, migraine head aches and cardiac or renal dysfunction, require careful observation and documentation to avoid serious complications. Danocrine also has a known drug interaction with the drug Warfarin, causing a noteable increase in Carbamzepine levels in patients taking both drugs.
Additionally, since hepatic dysfunction manifested by modest increases in serum transaminases levels has been reported in patients treated with Danocrine, period liver function testing is advisable. Administration of Danocrine has been reported to cause manifestations of acute intermittent porphyria.
What are he uses of Danocrine and how does it work?
Danocrine is commonly used as a treatment for Endometriosis, Fibrocystic breast disease and hereditary Angioedema. Danocrine suppresses the pituitary-ovarian axis and is thought to achieve this effect by a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of danazol with sex hormone receptors.
Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic when being used to treat endometriosis. The consequent changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danocrine on the pituitary-ovarian axis. A complete cure of endometrial lesions occurs in the most cases.
When the drug is used to treat fibrocystic breast disease, a complete disappearance of the disease's characteristic nodules is usually noted, as well as the elimination of pain and tenderness in the breast area. The treatment does tend to result in an irregular menstrual pattern but this is usually reversed within sixty to ninety days of the discontinuation of Danocrine therapy.
The drug is also used to prevent attacks of hereditary angioedema. This condition is disabling and can even be fatal if the edema occurs in a location that restricts the airway.

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