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Dapsone - All The Amazing Benefits Of Dapsone
December 1st, 2008

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Dapsone (chemically known as diamino-diphenyl sulphone) is a medication most commonly used in Multi-drug therapy in combination with clofazimine and rifampicin for the treatment of Mycobacterium leprae (leprosy.)

The working:

Dapsone is essentially an antibacterial and works by inhibiting the synthesis of dihydrofolic acid by bacteria. Sulfonamide groups of medicine work in a similar fashion.

The mechanism of dapsone is not clearly understood in the treatment of skin diseases in which bacteria play no role.

The benefits:
This medication has been successfully used for the treatment of skin diseases including leprosy and lichen planus. It has been proven instrumental in the treatment of various other serious and dangerous diseases including Bachet's disease, Cicatricial pemphigoid, and the Lupus erythematosus (LE.)
The side effects:

Although this medicine helps in the treatment of leprosy and related skin diseases, it can cause adverse side effects. Some of them are:

The effects of dapsone on the blood

1. Dose-related hemolysis leading to hemolytic anaemia is the most common side effect of this medication on blood along with methemoglobinemia.

2. Agranulocytosis is another disease which occurs lately on its own, but frequently when dapsone is used in combination for the treatment of malaria prophylaxis.

3. Dapsone has been reported to lead to abnormalities in the formation of white blood cells resulting in conditions such as aplastic anemia, a leading cause of dapsone related deaths.

Effects on the liver

Dapsone is known to have induced toxic hepatitis as well as cholestatic jaundice. Dapsone has also been known as an inhibitant to the Cytochrome P450 system. Other common adverse effects of the medicine include conditions such as nausea, headaches, and rashes. Although reversible, serious effects occur on the lungs. Patients using this medicine for the treatment of various skin disorders have also reported hypersensitivity. Reactions to Dapsone include rashes and also include eosiophilia, fever, and jaundice.

Dapsone— a century old medicine

Dapsone is a nearly century old medicine that has greatly aided the treatment of various skin related diseases like leprosy and lichen planus. The benefits of the medicine are generally out numbered by the possibility of diverse and dangerous side-effects. This medication can prove fatal for some patients and should be avoided in general for skin treatment. Other safer alternatives should be used. The steroids used in conjunction with dapsone as a part of the multiple drug therapy are extremely dangerous and possibly carcinogenic. This medicine as a whole is a drug which has positive aspects but the potential for serious side effects.

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