Florinef Acetate: What You Need To Know
November 22nd, 2008

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Florinef acetate is used as part of a partial replacement treatment for primary as well as secondary adrenocortical insufficiencies associated with Addison's disease and in treating salt-losing adrenogenital syndromes.

Ingredients

Florinef acetate comes in scored tablets for oral administration. Each tablet provides 0.1 mg of fludrocortisone acetate (active ingredient), corn starch, calcium phosphate, lactose, sodium benzoate, magnesium stearate, and talc.

Fludrocortisone

Fludrocortisone, the generic name for florinef acetate, is a synthetic corticosteroid with a moderate levels of glucocorticoid and a greater level of mineralocorticoid. It is primarily used in replacing the missing hormone aldosterone in different cases of adrenal insufficiencies like Addison's disease, and the salt-losing (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. On some occasions, it used in treating orthostatic hypotension too.

Dosage

Dosage varies from person to person and is highly dependent on how severe the condition is as well as how well the patient is responding to medication. Patients must be regularly monitored to check for signs of remissions or worsening of the disease, which would call for dosage adjustments when necessary.

Side effects

Stop taking fludrocortisone if you start to experience any of the following serious side effects, and see your doctor immediately:

l allergic reaction (breathing difficulties, swelling of the lips, face, or tongue, hives)
l swelling of the ankles or feet
l severe or continuous headaches
l dizziness / fainting spells
l increased levels of blood pressure (severe headache or blurring of vision)
l sudden gaining of weight (more than 5 pounds in one to two days)

Other side effects are attributed to long-term florinef acetate use. Consult your doctor if you are experiencing:

l nausea / stomach upset
l fatigue
l joint pains
l muscle weakness
l problems with controlling diabetes
l increased thirst or hunger
l thinning of the skin
l glaucomas
l cataracts
l osteoporosis

Drug interactions

Before starting use of fludrocortisone, advise your doctor if you are currently taking any of the following:

l barbiturates like amobarbital, secobarbital, pentobarbital, or phenobarbital
l birth control pills
l estrogen medications
l diuretics
l insulin or oral diabetic medication
l anabolic steroids
l phenytoin or ethotoin
l rifampin
l digoxin
l amphotericin B
l warfarin
l aspirin

If the following drugs are being taken for other treatments, you might need dosage adjustments for fludrocortisone. Apart from those mentioned above, there are other drugs that might interact with fludrocortisone as well. To be safe, mention every medication you are taking (prescription or over-the-counter) to your doctor before starting fludrocortisone use. These would include even regular vitamin supplements and herbal products.

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